This article effectively highlights design challenges for high resolution screens. Locking in max-width is a limiting and oftentimes detrimental approach. With responsive design one needs to consider big screen opportunities as well as small screen compatibility. How can you take advantage of high resolution? Consider content strategy and the opportunity to keep more content above the fold. The plethora of examples along with discussion on how others have utilized the big screen are what really make this article useful.
CSS3 offers two key techniques for responsive designs across resolutions. One that shows the most promise is CSS regions. Also look at CSS columns and design around a strong grid.